Treponema pallidum Reiter株の抗原構造分析と梅毒血清反応における意義
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概要
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A series of studies has been conducted about the antigenic structure of the Reiter Strain of Treponema pallidum using a refined Reiter protein antigen purified by lower phase solvent adapting the Agar Gel Diffusion test and Complement Fixation test. Through these studies, the existence of the common antigen between the Reiter strain and pathogenic treponema (Nichols strain) was observed and furthermore this chemical component was acknowledged as the protein. However, the removal of appearance of the nonspecific reaction was nearly impossible at the RPCF test using this purified Reiter antigen.This should be considered, as the author has refered previously, to be caused by the common antigen of the saprophytic treponema existing in the healthy human.On the other hand, the positive reaction was observed at the serologic test for the human serum from the syphilitic individual absorbed by the Reiter strain using the pathogenic treponema (Nichols strain) as an antigen, and from this results, it was found the Reiter strain has only the common antigen which is exist among treponemes except own specific antigen, and the pathogenic treponema has the specific antigen other than the Reiter strain.From the test aforementioned the usage of the Reiter strain as an antigen at Complement Fixation test is not appopriate, and rather it should be used as an absorption antigen for nonspecific reaction caused by the common antigen among treponemes at the test involving the Fluorescent Treponemal Antibody test where the pathogenic treponema is being used as an antigen.
- 日本細菌学会の論文