BCG接種マウスのインフルエンザ・ウイルス静注毒性に対する抵抗性の変化について-2-
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BCG-injected mice showed an increase (30%) in the weight of the liver and increase (150%) in the weight of the spleen as compared with control mice, at the 11th day after BCG injection.In histological observations, in the liver of the mice were exhibited an infiltration with neutrophils and lymphocytes, multiplication of the Kupffer cells and degeneration of liver cells.In the spleen of the mice were showed a hypertrophy of follicles an proliferation of reticulo-endothelial cells.When the reticuloendothelial system of mice was blocked by Pelikan india ink, the mice showed a decrease (75%) in the LD50 for E. coli endotoxin, however showed no significant alteration of the LD50 for the PR8 strain of influenza A virus.In the peripheral blood picture of BCG-injected mice, an increase (120%) in the number of neutrophils was observed. An increase (20%) in the number of leucocytes was also observed.The results of cellulose acetate electrophoresis indicated a decrease in albumin, increase in α and β plus γ globulins and lowered albumin: globulin ratio (A/G ratio) in response to BCG infection in mice.A little increase in the serum protein concentration of BCG injected mice was observed.The hemagglutination inhibiting antibody titres of the sera of BCG injected and control mice were both lower than 1: 10.There were observed only a little permeability to Trypan blue of control mice's and rabbits' and also BCG-injected animals' skins after the administration with the PR8.This fact suggested that the more sensitive test of the permeability of blood vessel would be required.