実験的感染症における感染防禦機構に関する研究-1-

概要

論文の詳細を見る
There have been many recent studies on the phenomenon of "nonspecific" aquired resistance to infection and intoxication. It has been shown repeatedly that injection of vaccines or endotoxins prepared from Gram-negative bacteria alters host susceptibility to subsequent infections with homologous or heterologous bacteria. The present investigations were undertaken to compare the effects of the pretreatments with some bacterial endotoxins and their pretreatment routes on resistance of mice to typhoid cerebritis. Results: 1. The effects of three different pretreatment routes, cerebral, peritoneal and subcutaneous, were compared on the protection of mice encephalitis. Cerebral treatment was shown to be the most effective one in these three routes. 2. Endotoxins were more effective than heat killed vaccines and the homologous endotoxin prepared from Salmonella typhimuriumwas more effective than the other two endotoxins prepared from heterologus bacteria. 3.Pretreatment with small doses of endotoxin could not protect mice from intracerebral challenge with lethal dose of endotoxin 48 hr after the pretreatment.
日本細菌学会の論文