腸炎ビブリオ抽出核酸の生物学的ならびに免疫学的意義に関する研究-2-
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概要
- 論文の詳細を見る
It was demonstrated in the author's 1 st report that DNA fraction isolated from Vibrio parahaemolyticus had lethal toxic effect to mice. In this report the immuno-serological studies on the DNA isolated from Vibrio parahaemolyticus were carried out. Purified DNA derived from Vibrio parahaemolyticus was injected intramuscularly to rabbits with complete adjuvant. High anti-DNA fraction titer was demonstrated by sensitized haemaggulutination reaction. The pretreatment by immunized rabbit serum with DNA fraction was found to have remarkable protective action against the challenge of 10 times doses of toxic fraction and remarkable protective effect against infection with Vibrio parahaemolyticus. These immuno-serological results also suggest that DNA derived from Vibrio parahaemolyticus might have a significant role.
- 日本細菌学会の論文