抗酸菌の物質代謝に関する研究

概要

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For the purpose of differentiating various kinds of acid-fast bacilli, especially M. tuberculosis var. hominis and atypical mycobacteria, we performed studies on their respiration using Warburg's manometer.<BR>The acid-fast bacilli we examined are: M. tuberculosis var. hominis (three strains), BCG, M. avium (strain Kirchberg), non-pathogenic mycobacteria (five strains), atypical mycobacteria (five strains) isolated by us, and stypical mycobacteria originated in U. S. A.<BR>Glycerine, lactic acid, succinic acid, pyruvic acid and dodecan are added as a substrate in manometer and oxygen absorption rate of each group are observed. The oxygen absorption rate of atypical mycobacteria showed remarkable increase, only when dodecan is added. The rate of M. tuberculosis var. hominis and non-pathogenic mycobacteria, on the contrary, showed rather lower levels than their self-respiration rate. On the cases of BCG and Kirchberg's strain, the rate increased not only with dodecan, but also with glycerine and salicylic acid.<BR>As the results of these findings, we can conclude that M. tuberculosis var. hominis, atypical mycobacteria, and non-pathogenic mycobacteria might be easily differentiated from the aspects of respiratory metabolism, if we compare their respiration rate under dodecan, glycerine and salicylic acid.
日本細菌学会の論文