X線照射による白血球減少家兎に対するanti-leucopenic action

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1. A Single intravenous injection of 1.0-2.0 mg of Marinamycin (M2), 2-4 hrs. before the whole bodyirradiation of X-ray (182 γ), showed the preventive effect for rabbits from leucopenia. At the same dosage of irradiation, three prior intravenous injection of Adenine sulfate (10mg×3), showed the similar result. 2. The natural recovery of leucopenia produced on rabbits irradiated by 182 or 300 γ took the same period of 73 days. The injection of 5.0 mg M2, 2 hrs. or 48 hrs. prior to irradiation (300 γ), prevented the acute leucopenia, but did not showed the same effect in the case of 24 hrs. prior injection. 3. The administration of M2 after the irradiation (300 γ) showed the rapid recovery effect for leucopenia. 4. The administration of Benzyl Kinetin prior to the whole-body irradiation (300 γ) did not preventthe leucopenia. 5. The leucopenia caused by the administration of the anti-cancer antibiotics (Carcinophilin and Mitomycin C) was recovered by the M2 treatment.
日本細菌学会の論文