結核免疫における特異性の研究-2-

概要

論文の詳細を見る
Change in susceptibility of mice to bacterial endotoxin was summerized as follows: 1. Mice pretreated with unclassified mycobacteria increased the susceptibility to bacterial endotoxin as BCG-immunized mice. The increase in susceptibility to bacterial endotoxin was conspicuous in order of photochromogen P-16, scotochromogen Watanabe, non-photochromogen Ueda. Non-photochromogen 121326 strain did not increase the susceptibility to endotoxin. 2. The increase in susceptbility to bacterial endotoxin following infection with unclassified mycobacteria was associated with proliferative ability of infected strains in vivo, but BCG-immunized mice showed a remarkable increase in the susceptibility in spite of weak bacterial multiplication in organs. 3. There was no parallelism between the immunity reported in previous reports and the increase of susceptibility to bacterial endotoxin reported here. 4. Previous and present experimental results led to the conculusion that protective mechanism of unclassified mycobacteria to infection with human tubercle bacilli is different from that of BCG.
日本細菌学会の論文