サルモネラ菌によるマウス感染初期反応の追究 : I. 感染初期における網内系の役割
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概要
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Studies on the role of the reticuloendotherial system (abbr. RES) in the early phase in mice infected with Salmonella were carried out.<BR>Salmonella typhimurium as a virulent strain, Salmonella typhi as an avirulent strain and hybrid No.19 (a recombinant between Salmonella typhimurium and Escherichia coli), which is avirulent in mice but is antigenically identical with Salmonella typhimurium, were used. Intravenous injections of these trains did not show a significant difference in the uptake by the RES in the early phase of infection.<BR>After previous treatment of the RES with heat-killed Salmonella typhimurium, living hybrid No.19 and thorotrast as a blocking colloidal material, the challenge of living Salmonella typhimurium into mice was employed. In the pretreatment with thorotrast it was clearly observed that the clearance of bacteria from the blood stream was depressed, the interval to the death by infection was shortened and a considerable amount of bacteria multiplied in the liver, the spleen, and the mesenteric lymphnode.<BR>Using the carbon method as a RES function test, “blockade” was intensively observed in thorotrattreated mice.<BR>The significance of the role that the RES plays in the early phase of infection, was discussed.