Acetylene誘導体に関する研究 : 第1報2, 4, 5-trichlorophenyl-γ-iodopropargylの抗白癬作用について
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概要
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The authors found interesting results on acetylenic compounds by microbial and animal tests, which are described herein.<BR>It is known that same acetylenic compounds such as dicarbamoylacetylen (Collocidin: Lenamycin) and Capillin have antimicrobial activity. During the course of the synthetic study in this laboratory to find those acetylenic compounds with antimicrobial activity, we came to new compounds, halophenyl-γ-iodopropargyl ethers which have very potent activity on fungi and some other microbes. Among these compounds, 2, 4, 5-trichlorophenyl-γ-iodopropargyl ether had each minimal inhibitory concentration of 0.25γ/ml, 0.25γ/ml, 0.78γ/ml against Trichophyton asteroides, T. interdigitale, T. rubrum and also showed rather high activity for other fungi, Cryptococcus, Staphylococcus, Streptococcus, Bacillus subtilis, Mycobacterium in dilution assay.<BR>The high activity of the compound for Trichophyton in vitro was also proved by the curative effects ton infectious animal tests.(guinea-pig)
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