無菌マウスおよび自然マウス腸管内における腸内細菌の薬剤耐性伝達
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概要
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The transfer of the drug resistance of enteric bacteria in the intestine of germfree and conventionalmice was studied with Shigellae, Escherichiae, and Klebsiellae.<BR>Using mostly the technique described by Freter (1956), these organisms from a 24 hour broth culturewere given to the mice by stomach tube. Of course, antibiotics water were not given throughout the courseof the experiment after challenge of drug sensitive bacteria.<BR>Results obtained are as follows;<BR>1) All of the resistance factors (Streptomycine, Chloromycetin, Tetracycline, and Sulfathiazole) wereeasily transferred, when donor and recipient multiplied together in the mouse intestine.<BR>2) Transferred resistance was further retransferred to sensitive enteric bacteria in the mouse intestine.<BR>3) From four out of six experiments, resistance-transferred bacteria showed equal level and patternof resistance in each group. In two experiments, two kinds of resistance pattern were found in the transferredbacteria, but all transferred bacteria in each group showed the equality of resistance level.<BR>4) From the experiment, the transferred resistance is exactly equal, when it is passed from onedonor to other genus-differing recipients, nevertheless, if the transmission occurs between donors from differentgenus and the same recipient, the transfer-result might differ, or otherwise, equal. Therefore, it seemsthat transferred resistance factors are rather determined by donor than recipient.<BR>5) On the conclusion, it is also believed that the generation of the resistance in the human entericbacteria is due to the transmission of resistance against drug from one previously existing enteric bacteria tothe next-comer.
- 日本細菌学会の論文