鼠癩における宿主抵抗と病型の関係-9-

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As stated in the preceding report, agouti mice of (C3H×ddY) Fl were characteristic in their response to subcutaneous inoculation with murine leprosy bacilli, roughly half of them being of malignant type and the rest being of benign type of mouse leprosy. However, when these Fl hybrids had been vaccinated with BCG, challenge lesions took the feature of benign type in all cases. This observation led us further to the study on the influence of primary infection with murine leprosy bacilli, instead of BCG, upon the leproma development of superinfection in these F1 hybrids.<BR>Mice of (C3H×ddY) F1 were infected subcutaneously with murine leprosy bacilli. Superinfection was made by subcutaneous inoculation 16 weeks later only in the mice of these F1 hybrids, showing malignant leproma at the site of primary infection.<BR>About half of superinfected mice showed intermediate but rather benign leproma at the challenged site. In the remaining mice, however, the lesions of superinfection were malignant or intermediate but nearer to malignant type. Thereupon, the typical benign leproma could not be observed in all experimental animals.<BR>It may be stated as a conclusion from the result of this experiment that murine leprosy primary infection can not convert the superinfection from the malignant type to the benign type unlike BCG vaccination.
日本細菌学会の論文