野兎病菌における干渉現象の細菌学的研究 : I. モルモヅト, ウサギの実験

概要

論文の詳細を見る
Evans et al. in 1954 demonstrated that the early protection produced in mice by the injection of pertussis vaccine against the challenge with Haemophilus pertussiswas different from the immune phenomenon as mediated by antibodies and reported it as interference phenomenon. In fact, they were the first to take notice of interference phenomenon between becteria. The present authors observed the similar phenomenon with Bacterium tularense. The results of our tests revealed that when mice were challenged with virulent strains of Bacterium tularense within a short period after the injection of avirulent or inactivated strains of the organisms, they were alive for a longer period as compared with the control animals, or some of them could survive the challenge. This phenomenon was exhibited in guinea-pigs which have almost the same susceptibility with mice and also in rabbits which are higher in natural resistance than guinea-pigs and mice. In the test made using other species of becteria and viruses as interfering agents, brucella gave the phenomenon to some extent but viruses did not so, indicating that this was a non-specific phenomenon. In the mice which experienced the interference phenomenon, even if they were succumbed to the challenge, the pathological changes were macroscopically slighter than the control and the challenge organisms were hardly detectable in the lesion. The mice surviving the challenge looked almost the same with the mice immunized.
日本細菌学会の論文

野兎病菌における干渉現象の細菌学的研究 : I. モルモヅト, ウサギの実験

スポンサーリンク

概要

著者

関連論文

スポンサーリンク