Development of Iron Deficiency Decreases Zinc Requirement of Rats

スポンサーリンク

概要

• 論文の詳細を見る

• Effects of the development of Fe deficiency on changes in Fe and Zn metabolism and its possible interactions with dietary Zn were determined. Adequate (25μg/g) and marginally deficient (5μg/g) Zn diets containing a sufficient (40μg/g) dietary Fe levels were fed for 2 wk. Thereafter, both dietary Zn groups were fed an Fe-deficient (2.2μg/g) diet for 4 wk. It was found that the effects of an Fe-deficient diet began to occur 7 and 14 d after feeding the Fe-deficient diet. At this time, tissue Fe concentrations were depleted and rats were unable to maintain hemoglobin levels. The Fe deficient diet also induced an immediate fall in plasma Fe concentration, transferrin saturation, and apparent Fe absorption, while the concentrations of liver cytochrome c increased as Fe deficiency developed. Decreases in liver and spleen Fe levels, as well as the activities of blood and bone marrow aminolevulinic acid dehydratase (ALA-D, EC 4.2.1.24) were observed 3, 7, and 14 d after feeding the Fe-deficient diet, and thereafter they were increased. On the other hand, the activity of plasma alkaline phosphatase (ALK-P, EC 3.1.3.1) decreased continuously as Fe deficiency progressed. With severe development of Fe deficiency, rats fed the Zn-adequate diet had increased levels of Zn concentration in the plasma, liver, spleen, kidney, and femur, whereas apparent Zn absorption was decreased. The decrease in apparent Zn absorption and the increase in tissue Zn concentration of rats might be related to the lowered Zn requirement, which is associated with the depressed Zn metabolism caused by feeding Fe-deficient diets.

• 財団法人 学会誌刊行センターの論文

著者

• Kaganda Joyceline

  Department Of Biochemistry And Food Science Faculty Of Agriculture Kagawa University

• Suzuki Hiroo

  Department Of Biochemistry And Food Science Kagawa University

• Matsuo Tatsuhiro

  Department of Biochemical Science and Technology, Kagoshima University

• Matsuo Tatsuhiro

  Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University

関連論文

• Development of Iron Deficiency Decreases Zinc Requirement of Rats
• Antitumor and Cytotoxic Effects of Phyllanthus polyphyllus on Ehrlich Ascites Carcinoma and Human Cancer Cell Lines
• Enhancement of antimicrobial activities of cefteram or clavulanic acid/amoxicillin against cefixime-resistant Neisseria gonorrhoeae in the presence of clarithromycin or azithromycin
• Enterovesical fistula caused by non-Hodgkin's lymphoma of the ileum : report of a case
• Protein Utilization in Rats during Early Stages of Zinc Deficiency
• Development of Iron Deficiency Decreases Zinc Requirement of Rats
• Daily Rice Intake Strongly Influences the Incidence of Metabolic Syndrome in Japanese Men Aged 40-59 Years

スポンサーリンク