ASCORBIC ACID METABOLISM IN HYPERTHYROID RATS

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Male albino rats were fed thyroid powder (1%) and ascorbic acid, dehydroascorbic acid, and diketogulonic acid were determined in liver, kidney, and urine, while only total ascorbic acid was determined in blood, after 14 days. Activities of ascorbic acid-synthesizing enzymes D-glucurono-δ-lactone hydrolase, L-gulono-γ-lactone hydrolase, L-gulono-γ-lactone oxidase were estimated in liver. The activities of degrading enzymes dehydroascorbatase and 2, 3-diketoaldonate decarboxylase were studied in liver and kidney. In hyperthyroid rats there was a significant decrease in the ascorbic acid level and dehydroascorbic acid content of liver, and urine. On the other hand there was marked in-crease in the diketogulonic acid of liver and kidney. The content of ascorbic acid and dehydroascorbic acid in urine of hyperthyroid rats decreased significantly, while there was an increase in diketogulonic acid content. There was a slight decrease in the total ascorbic acid in blood. A significant decrease was found only in activities of L-gulono-γ-lactone oxidase, while no change in the activities of D-glucurono-δ-lactone hydrolase and L-gulono-γ-lactone hydrolase occurred. An appreciable increase in the activity of dehydroascorbatase, with unchanged activity of 2, 3-diketoaldonate decarboxylase, was observed in liver and kidney.
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