The relation between urinary excretion of tryptophan and niacin metabolites and pyridine nucleotides in the liver in rats fed a tryptophan-deficient diet.

概要

論文の詳細を見る
The determination of nicotinamide adenine nucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) levels in the liver and urinary excretion of tryptophan niacin metabolites were made in rats fed a tryptophan-deficient diet. Under experimental conditions excretion of N1-methyl-2-pyridone-5-carboxiamide (pyridone) decreased by approximately one-third in the tryptophan-deficient group when compared with the control group. A rapid decrease in body weight was shown in the tryptophan-deficient group when compared with the control group. The level of NAD+ and NADP+ and total PN+ in the tryptophan- and niacin-deficient group was decreased significantly when compared with other deficient group (niacin- or nicotinamide-added group) and the control group except for NADP+. No statistical difference was seen on the addition of nicotinic acid or nicotinamide. But a slightly lower level of urinary nicotinic acid was observed in the group with nicotinamide added when compared with group with nicotinic acid added. Simultaneously, a high level of NAD+ was observed in the group with nicotinamide added. Thus, a difference in availability between nicotinic acid and nicotinamide might be expected.
財団法人学会誌刊行センターの論文