The influence of thiamine deficiency on porphyrin synthesis and porphyrin proteins.

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概要

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• 1. Studies carried out in cell-free rat-liver extracts showed an inhibitory effect of thiamine deficiency on porphyrin synthesis. 2. Extracts of normal and thiamine-deficient rat livers were incubated with the cofactors and substrates of the thiamine pyrophosphate-dependent enzyme, 2-oxoglutarate glyoxylate carboligase. There was a marked inhibition of porphyrin synthesis when the substances were added either individually or together. 3. Thiamine deficiency resulted in a decrease of haemoglobin concentration and catalase activity whereas a rise in tryptophanpyrrolase activity and cytochrome b5 and P450 concentration was observed.

• 財団法人 学会誌刊行センターの論文

著者

• HAUSCHILDT S.

  Institut für Ernährungswissenschaft I der Justus-Liebig-Universität Giessen

関連論文

• Comparative studies between rates of incorporation of branched-chain amino acids and their .ALPHA.-ketoanalogues into rat tissue proteins under different dietary conditions.
• The influence of thiamine deficiency on porphyrin synthesis and porphyrin proteins.

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