THE EFFECTS OF ASCORBIC ACID ON DIPHTHERIA TOXIN AND INTOXICATED HELA CELLS
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概要
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Ascorbic acid (vitamin C) prevented diphtheria toxin from inhibiting the incorporation of [U-14C]-alanine into trichloroacetic acid precipitable material in HeLa cells. Ascorbic acid did not exhibit an effect on the adenosine diphosphate-ribosylation of amino acyl trans ferase II nor did it separate fragment A from fragment B in “nicked” toxin. A non-specific reducing agent, para-methylaminophenol sulfate, exhibited an effect on HeLa cells very similar to the results of ascorbic acid. Citric acid, a tricarboxylic acid, had no effect on HeLa cells.
- 財団法人 学会誌刊行センターの論文
著者
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Clark Charles
Department Of Health Sciences College Of Health East Tennessee State University
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Smith Timothy
Department of Health Sciences, College of Health, East Tennessee State University
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Smith Timothy
Department Of Anthropology University Of Pittsburgh
関連論文
- 6.ジフテリア毒素及びジフテリア毒素感染Hela細胞に対するビタミンCの効果(JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY Vol.22 No.4(掲載論文要旨))
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