VITAMIN B12 LEVELS OF CEREBROSPINAL FLUID IN PATIENTS WITH A VARIETY OF NEUROLOGICAL DISORDERS

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概要

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• The vitamin B12 levels of cerebrospinal fluid were assayed microbiologically (Lactobacillus leichmannii method) using samples from 44 patients with various neurological disorders, 4 patients with megalo-blastic anemia and 34 controls. Twenty-seven controls that did not receive vitamin B12 showed a mean cerebrospinal fluid vitamin B12 level of 21.5 pg/ml (range: 0-60). No decrease in cerebrospinal fluid vitamin B12 level was seen in patients with subacute myelo-optico-neuropathy (SMON). High levels of cerebrospinal fluid vitamin B12 were observed only in the patients receiving long term administration of the vitamin. Intrathecal administration of vitamin B12 caused only a slight increase in serum vitamin B12 level after four hours. The existence of a blood brain barrier for vitamin B12 was suggested.

• 財団法人 学会誌刊行センターの論文

著者

• 田口 博國

  Central Laboratories, Okayama University Medical School

• 真田 浩

  Central Laboratories, Okayama University Medical School

• 原 功一

  Department of Internal Medicine, Okayama University Medical School

• 三好 勇夫

  Department of Internal Medicine, Okayama University Medical School

• 平木 潔

  Kochi Medical School

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• VITAMIN B12 LEVELS OF CEREBROSPINAL FLUID IN PATIENTS WITH A VARIETY OF NEUROLOGICAL DISORDERS

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