EFFECT OF NITROGEN SOURCE ON NUTRITIONAL MANAGEMENT AFTER SMALL BOWEL RESECTION IN RATS

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Nutritional effects of dietary nitrogen sources on rats subjected to 65% distal resection of the small bowel were compared at the 2.4% nitrogen level, i.e., by feeding the rats a diet which contains 2.4% nitrogen from various sources. The nitrogen sources used were casein (C), the casein-simulated amino acid mixture (F), the proposed amino acid mixture (T-2), which was devised in our laboratory, and the amino acid-casein mixture (R), in which 25% of the proposed amino acid mixture was replaced by isonitrogenous casein. All the experimental diets were made cellulose-free. Total weight gains of the resected groups during three weeks were less than those of the corresponding unresected groups because of the depressed gains in the first postoperative week. In the resected rats, as well as in the unresected rats, the maximum total weight gain was obtained with diet R and followed weight gains with diet C, diet F, and diet T-2. Fecal weight increased moderately in the resected rats but the degree of the increase was not influenced by the type of dietary nitrogen source. Dry weight of intestinal remnants in creased markedly within one week after resection. The extent of hyper plasia was not altered by the type of dietary nitrogen source. These results indicate that an amino acid mixture partially replaced with casein may be a useful dietary nitrogen source for short gut syndrome.
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