Anti-riboflavin activity of 8-O-alkyl derivatives of riboflavin in some gram-positive bacteria.

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概要

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• Two new 8-O-alkyl derivatives of riboflavin (RF), i.e., 8-methoxy- (MOF), and 8-ethoxy-8-demethyl-D-riboflavin (EOF), their tetraacetate, and the tetraacetate of 8-hydroxy-8-demethyl-D-riboflavin (HOF) were synthesized. The anti-RF activity of MOF, EOF and HOF was estimated from the ratio CR/CI, where CI is the concentration of test flavin added to the culture medium and CR is the minimum concentration of RF needed to restore the growth inhibition. Their activity was also compared with that of roseoflavin (RoF). The decreasing order of anti-RF activity was as follows: MOF>RoF>EOF in Sarcina lutea; RoF>MOF>EOF in Bacillus cereus and Staphylococcus aureus. HOF showed no activity in any of the bacteria tested. The redox potential of these compounds decreases as follows: RF>RoF>EOF>MOF>HOF, and the anti-RF activity of MOF and EOF could be explained by the redox potential difference between these compounds and RF.

• 財団法人 学会誌刊行センターの論文

著者

• 松井 邦夫

  Division of Biology, Research Institute for Atomic Eergy, Osaka City University

• 笠井 佐夫

  Division of Biology, Research Institute for Atomic Energy, Osaka City University

• 山中 成子

  Division of Biology, Research Institute for Atomic Energy, Osaka City University

• 王 秀娟

  Division of Biology, Research Institute for Atomic Energy, Osaka City University

関連論文

• Chemistory and Biochemistry of 8-Aminoflavins
• FLAVIN AND MELANIN IN CAT AND DOG CHOROIDS
• EFFECT OF 8-AMINO-8-DEMETHYL-D-ARABOFLAVIN, 8-AMINO-8-DEMETHYL-D-RIBOFLAVIN AND 8-HYDROXY-8-DEMETHYL-D-RIBOFLAVIN ON MICE
• Anti-riboflavin activity of 8-O-alkyl derivatives of riboflavin in some gram-positive bacteria.
• Anti-riboflavin activity of 8N-alkyl analogues of roseoflavin in some gram-positive bacteria.
• Identification of Riboflavinyl α-D-Glucoside in Cat Liver
• FLAVIN CONTENT IN CAT AND DOG CHOROIDS

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