Anti-oxidative effects of vitamin B2-butyrate on the cardiac mitochondrial disorders induced by adriamycin.

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概要

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• The combined use of CoQ10 with adriamycin has beenrecommended for reduction, of the cardiotoxicity that occurs during cancer chemotherapy. Vitamin B2-butyrate was also investigated in order to determine anti-oxidative effects on adriamycin cardiotoxicity. This vitamin analysis prevented enhanced lipid peroxidation and rectified the respiratory disorders of heart mitochondria induced by adriamycin, however, the deficiency of the CoQ10-pool was not rectified. The combined approach of using CoQ10 for rectifying the deficiency of this component and of using B2-butyrate for reducing lipid peroxidation was indicated for adriamycin cancer chemotherapy.

• 財団法人 学会誌刊行センターの論文

著者

• GRIFFIN A.

  M. D. Anderson Hospital and Tumor Institute

• 小倉 良平

  Department of Medical Biochemsitry, Kurume University School of Medicine

• 香月 司

  Department of Medical Biochemsitry, Kurume University School of Medicine

• DAOUD Abdulwahid

  M. D. Anderson Hospital and Tumor Institute

• 小倉 良平

  Department of Medical Biochemistry, Kurume University School of Medicine

関連論文

• Anti-oxidative effects of vitamin B2-butyrate on the cardiac mitochondrial disorders induced by adriamycin.
• Effect of riboflavin-butyrate on cardiac glutathione reductase affected by adriamycin.

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