Effects of Treatment with Thiamin Antagonists, Oxythiamin and Pyrithiamin and of Thiamin Excess on the Levels and Distribution of Thiamin in Rat Tissues

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概要

• 論文の詳細を見る

• Levels of thiamin and its derivatives in brain, heart and liver were determined in control, thiamin-deficient, pyrithiamin-treated and oxythiamin-treated rats at various times after the start of treatment. With 10μg of thiamin/100g/day subcutaneously, rats rapidly lost thiamin from the tissues until growth maintenance levels were reached. Oxythiamin had a minimal further effect on tissue thiamin while pyrithiamin caused further marked reduction. With higher levels of thiamin intake, tissue thiamin levels increased with intakes of up to 150-200μg/ 100g/day after which they did not show any further significant increase. Levels of pyrithiamin above 50μg/ 100g/day for 20 days had only minimal further effect upon tissue thiamin levels over that with 50μg.

• 財団法人 学会誌刊行センターの論文

著者

• GUBLER C.

  Graduate Section of Biochemistry, Brigham Young University

• MURDOCK D.

  Graduate Section of Biochemistry, Brigham Young University

• Gubler C.J.

  Graduate Section of Biochemistry, Brigham Young University

• Murdock D.S.

  Graduate Section of Biochemistry, Brigham Young University

関連論文

• Effects of Treatment with Thiamin Antagonists, Oxythiamin and Pyrithiamin and of Thiamin Excess on the Levels and Distribution of Thiamin in Rat Tissues
• BIOCHEMICAL CHANGES IN THIAMINE DEFICIENCIES

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