Effects of Leucine/Isoleucine Ratio in Amino Acid Mixture-Diets Simulating Normal and High-Lysine Maize Proteins on Growth, Nitrogen Balance, and Tryptophan-Niacin Metabolism in Rats

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概要

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• To re-evaluate nutritive values of opaque-2 (02) and brittle-2 opaque-2 (bt2O2) maize protein and to re-estimate Gopalans hypothesis [Lancet, i, 954-957 (1960)] that pathogenesis of pellagra might be related with intake of excess leucine and with chronic consumption of maize or jowar which contains relative high leucine, rats were fed on synthetic diets composed of amino acid mixtures simulating the protein of normal and high-lysine maize, O2 and bt2O2 maize. In order to investigate the effect of intake of excess leucine, leucine was supplemented to 02 and bt2O2 diet at the level of 0.43 and 0.73%, respectively, to adjust the ratio of leucine to isoleucine to that of normal maize protein. Judging from body weight gains and carcass nitrogen of weanling rats fed on these diets, the protein quality (amino acid composition) of bt2O2 maize was 30% superior nutritionally to that of 02 maize, and body composition of bt2O2 diet group were similar to that of casein diet group. Leucine supplementation did not affect these values except for a significant de-crease in plasma valine levels. In young adult rats fed on leucine supplemented 02 diet, excretion of urinary nitrogen increased significantly compared with 02 diet alone, suggesting that a slight amino acid imbalance took place. But leucine supplementation altered neither N1-methylnicotinamide level in urine nor total niacin levels in the liver and the brain. These results suggest that supplementation of leucine to a high lysine maize diet did not affect tryptophan and niacin metabolism in rats under these conditions.

• 財団法人 学会誌刊行センターの論文

著者

• 不破 英次

  Department of Food and Nutrition, Osaka City University

• 小西 洋太郎

  Department of Food and Nutrition, Osaka City University

関連論文

• Some Properties of Starches of Opaque-2, Sugary-2 Opaque-2, and Waxy Opaque-2 Mutants of Two Broad-Based Synthetic Cultivars of Maize
• Effects of Leucine/Isoleucine Ratio in Amino Acid Mixture-Diets Simulating Normal and High-Lysine Maize Proteins on Growth, Nitrogen Balance, and Tryptophan-Niacin Metabolism in Rats
• COMPARATIVE SUSCEPTIBILITY OF STARCH GRANULES OF DOUBLE- AND TRIPLE-MUTANTS CONTAINING AMYLOSE-EXTENDER, WAXY, SUGARY-1, SUGARY-2 AND DULL GENES OF MAIZE INBRED OH43 (ZEA MA YS L.) TO AMYLASE
• Some Properties of Large and Small Granules of Waxy Barley (Hordeum vulgare L.) Endosperm Starch
• COMPARATIVE SUSCEPTIBILITY TO AMYLASES OF STARCH GRANULES OF SEVERAL SINGLE ENDOSPERM MUTANTS REPRESENTATIVE OF FLOURY-OPAQUE, STARCH-DEFICIENT, AND MODIFIED STARCH TYPES AND THEIR DOUBLE-MUTANT COMBINATIONS WITH OPAQUE-2 IN FOUR INBRED LINES OF MAIZE
• Some properties of starches of grain amaranths and several millets.

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