Effects of Early Thiamin Deficiency and Subsequent Rehabilitation on the Cholinergic System in Developing Rat Brain

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概要

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• 1. The effects of thiamin deficiency during pregnancy and/or lactation on brain cholinergic system in rat pups were studied. Dietary rehabilitation for a period of 5 weeks from the 28th day was instituted to study possible ‘catch-up’ in the brain acetylcholine levels. 2. Brain acetylcholine level was found to be significantly decreased on the 21st and 28th days in pups of the dams fed thiamin deficient diet during gestation and lactation, whereas it was decreased on the 28th day in pups of the dams fed thiamin deficient diet during lactation. Activities of Cholinergic enzymes remained unaltered in both the deficient groups. 3. Subsequent dietary rehabilitation was found to reverse the deficits in brain acetylcholine levels.

• 財団法人 学会誌刊行センターの論文

著者

• Kulkarni A.

  Department Of Physics Kurukshetra University

• GAITONDE B.

  Department of Biochemistry, Haffkine Institute

• KULKARNI A.

  Department of Biochemistry, Haffkine Institute

• Kulkarni A.B.

  Department of Biochemistry, Haffkine Institute

• Gaitonde B.B.

  Department of Biochemistry, Haffkine Institute

関連論文

• Role of the Adjustable Parameter Q_c Occurring in the Resonance Theory
• Effects of Early Thiamin Deficiency and Subsequent Rehabilitation on the Cholinergic System in Developing Rat Brain
• THE CONVULSIVE ACTION OF 2, 5-DICARBETHOXY 3, 4-DIHYDROXYTHIOPHANE (DICETOL)
• PHARMACOLOGICAL ACTIONS OF BERBERINE ON THE CENTRAL NERVOUS SYSTEM

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