Effect of Chronic Administration of Riboflavin 2, 3, 4, 5-Tetrabutyrate on the Hepatic Enzymes of Fatty Acid Oxidation in the Rat

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Effects of long-term administration of riboflavin, sodium butyrate or riboflavin 2, 3, 4, 5-tetrabutyrate (RTB) on the activities of renal and hepatic enzymes that catalyze the β-oxidation of fatty acid were determined in the rat. Feeding of riboflavin or sodium butyrate for 5 weeks had no effect on all the enzymes examined. By contrast, feeding of RTB resulted in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase [EC 2.3.1.16] by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase [EC 6.2.1.3] and acyl-CoA dehydrogenase [EC 1.3.99.3] remained unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged RTB administration results in an increased β-oxidation of fatty acid in the liver, which may explain the reported reduction in the concentration of tryglyceride in plasma during RTB treatment.