Active site of intestinal .GAMMA.-glutamyltransferase faces luminal side of brush border membrane.

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概要

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• Purified γ-glutamyltransferase from hog small intestine was competitively inhibited by glutathione in vitro when L-γ-glutamyl -p-nitroanilide was used as a substrate. An S-acetyldextran derivative of glutathione inhibited the enzyme as well as glutathione, although dextran had no inhibitory effect. γ-Glutamyltransferase in the rat small intestine could utilize in situ L-γ-glutamyl-p-nitroanilide circulated in the lumen, and was inhibited by the impermeable derivative of glutathione which was on the luminal side. These data suggested that the active site of intestinal γ-glutamyltransferase faced the luminal side of the brush border membrane.

• 財団法人 学会誌刊行センターの論文

著者

• 永田 幸雄

  Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

• 福山 肇

  Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

• 中村 征夫

  Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

• 鈴木 文昭

  Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

• 東 隆信

  Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University

関連論文

• EFFECT OF EXCESS L-HISTIDINE DIET ON ACCUMULATION OF L-HISTIDINE IN ISOLATED RAT SMALL INTESTINE
• Active site of intestinal .GAMMA.-glutamyltransferase faces luminal side of brush border membrane.

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