Active site of intestinal .GAMMA.-glutamyltransferase faces luminal side of brush border membrane.
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概要
- 論文の詳細を見る
Purified γ-glutamyltransferase from hog small intestine was competitively inhibited by glutathione in vitro when L-γ-glutamyl -p-nitroanilide was used as a substrate. An S-acetyldextran derivative of glutathione inhibited the enzyme as well as glutathione, although dextran had no inhibitory effect. γ-Glutamyltransferase in the rat small intestine could utilize in situ L-γ-glutamyl-p-nitroanilide circulated in the lumen, and was inhibited by the impermeable derivative of glutathione which was on the luminal side. These data suggested that the active site of intestinal γ-glutamyltransferase faced the luminal side of the brush border membrane.
- 財団法人 学会誌刊行センターの論文
著者
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永田 幸雄
Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University
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福山 肇
Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University
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中村 征夫
Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University
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鈴木 文昭
Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University
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東 隆信
Laboratory of Biological Chemistry, Department of Agricultural Chemistry, Faculty of Agriculture, Gifu University
関連論文
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- Active site of intestinal .GAMMA.-glutamyltransferase faces luminal side of brush border membrane.