Effects of vitamins on lipid peroxidation and suppression of DNA synthesis induced by adriamycin in Ehrlich cells.

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概要

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• The effects of various vitamins on lipid peroxidation and the suppression of DNA synthesis induced by adriamycin (ADR) in vitro using Ehrlich ascites carcinoma (EAC) cells were studied. ADR produced a concentration-dependent stimulation of lipid peroxidation in EAC cells. α-Tocopherol and coenzyme Q10 inhibited ADR-induced lipid peroxida-tion to about the same extent and these effects were the greatest for all antioxidants added. The inhibitory effect of riboflavin 2', 3', 4', 5'-tetrabu-tyrate was greater than that of riboflavin 5'-phosphate. On measuring incorporation of [3H]thymidine into EAC cells, these vitamins did not alter appreciably the magnitude of the ADR-induced suppression of DNA synthesis in EAC cells.

• 財団法人 学会誌刊行センターの論文

著者

• 小倉 良平

  Radioisotope Institute for Basic and Clinical Medicine, Kurume University School of Medicine

関連論文

• Effects of vitamins on lipid peroxidation and suppression of DNA synthesis induced by adriamycin in Ehrlich cells.

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