Long-Term Consumption of Whey Hydrolysate Formula by Lactating Women Reduces the Transfer of β-Lactoglobulin into Human Milk

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概要

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• Food antigens transferred into breast milk sometimes cause an allergic reaction in exclusively breast-fed infants. This study will show whether the intake of a whey hydrolysate formula for lactating women (MOM HA) can reduce the appearance of food antigens in breast milk. Lactating women in the MOM group (n=12) consumed MOM HA as a substitute for cows milk and those in the COW group (n=13) consumed cows milk for more than 4 months. After the ingestion of 200 mL of MOM HA and cows milk by the women in the MOM and COW groups, respectively, the first breast milk samples were obtained and β-lactoglobulin was measured using enzyme-linked immunosorbent assay. The number of subjects with detectable f3-lactoglobulin (>0.1 ng/mL) in the MOM group was two (17%), which was significantly less than that in the COW group (11 subjects, 85%, p<0.01). The level of β-lactoglobulin was also lower in the MOM group than the COW group (p<0.01). Subsequently, the women in the MOM group consumed cows milk and those in the COW group consumed MOM HA for one week; then a second sampling was performed. β-Lactoglobulin was detected in three (25%) and 8 subjects (62%) in the MOM and COW groups, respectively. The level of β-lactoglobulin was still lower in the MOM group (p<0.05). The consumption of whey hydrolysate formula by lactating women over a considerable time reduces the transfer of β-lactoglobulin into their breast milk, and the low level can be maintained even after inadvertent ingestion of cows milk.

• 財団法人 学会誌刊行センターの論文

著者

• FUKUSHIMA Yoichi

  Scientific Liaison Offece, Nestlé Japan Ltd

• Onda T

  Jikei Univ. School Of Medicine Tokyo Jpn

• KAWATA Yoichi

  Scientific Liaison Office, Nestle Japan Ltd., Shibuya-ku, Tokyo 150, Japan

• ONDA Takekazu

  Clinical Analysis Department, FALCO Biosystems, Inc., Kyoto 613, Japan 2 Department of Obstetrics an

• KITAGAWA Michihiro

  Clinical Analysis Department, FALCO Biosystems, Inc., Kyoto 613, Japan 2 Department of Obstetrics an

• Kawata Y

  Falco Biosystems Kyoto Jpn

• ONDA Takekazu

  Clinical Analysis Department, FALCO Biosystems, Inc., Kyoto 613, Japan 2 Department of Obstetrics and Gynecology, The Jikei University

• KITAGAWA Michihiro

  Clinical Analysis Department, FALCO Biosystems, Inc., Kyoto 613, Japan 2 Department of Obstetrics and Gynecology, The Jikei University

• FUKUSHIMA Yoichi

  Scientific Liaison Offece, Nestlé Japan Ltd

関連論文

• Preventive Effect of Whey Hydrolysate Formulas for Mothers and Infants against Allergy Development in Infants for the First 2 Years
• Long-Term Consumption of Whey Hydrolysate Formula by Lactating Women Reduces the Transfer of β-Lactoglobulin into Human Milk

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