Role of Enzymes in Tetrahydrobiopterin Biosynthesis: Computer Analysis of the Sequential Reaction of the Last Step

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概要

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• Computer simulation analysis of the experimental data showed that C1'-keto PH4 and C2'-keto PH4 were sequential intermediates of the reduction of PPH4 to BH4 by SPR and that the reaction in the last step of the BH4 biosynthesis proceeds as follows:<BR>PPH4→C1'-keto PH4 ⇒ C2'-keto PH4→BH4<BR>C1'-keto PH4 is not detectable in the reduction of PPH4 by the purified SPR at neutral pH since isomerization (⇒)[8] may occur far more rapidly than the first reduction(→).

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著者

• HIKITA H.

  Laboratory of Physics, Meikai University

• KATOH S.

  Deptartment of Biochemistry, Meikai University

• SUEOKA T.

  Deptartment of Biochemistry, Meikai University

関連論文

• Role of Enzymes in Tetrahydrobiopterin Biosynthesis: Computer Analysis of the Sequential Reaction of the Last Step

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