Morphogenetic Roles of Retinoic Acid
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概要
- 論文の詳細を見る
We integrated our information on morphogenetic roles of retinoic acid, focusing on development of chick limb. Retinoic acid has been considered to be a putative morphgen released from the ZPA. However, since exogenous retinoic acid induces expression of RAU, but not grafted ZPA, the ZPA is unlikely to produce retinoic acid. From the result that retinoic acid-treated cells induce digit duplication, retinoic acid converts anterior cells into ZPA cells. We found that retinoic acid also induces expression of homeobox genes indirectly and that bFGF enhances expression of the homeobox genes. Thus, we considered that retinoic acid and growth factors cooperate with each other to activate homeobox genes. A morphogenetic role of retinoic acid is to coordinate develpmental stage of each cells by controlling expression of homeobox genes.
- 財団法人 学会誌刊行センターの論文
著者
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Saito T.
Department of Cardiology Kokura Memorial Hospital
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Ide H.
Biological Institute,Tohoku University,Sendai.
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TANIGUCHI S.
Department of Metallurgy, School of Engineering, Tohoku University
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KOYAMA E.
Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine
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Nohno T.
Department Of Pharmacology Kawasaki Medical School
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NOHNO T.
Department of Pharmacology, Kawasaki Medical School
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NOJI S.
Department of Biochemistry, Okayama University Dental School
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