Structure of G-CSF: Significance of the Sugar Chain

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概要

• 論文の詳細を見る

• 1. The carbohydrate chain protects rhG-CSF from polymerization and/or conformational alterations associated with physicochemical changes, elevation of pH or temperature fluctuations.<BR>2. The carbohydrate chain of rhG-CSF prevents loss of its biological activity in normal human serum by inhibiting proteinase activity.<BR>3. These facts indicate that the carbohydrate chain of rhG-CSF has a markedly important role in maintaining the stability of the protein itself as well as in effecting the exertion of its biological activity.

• 財団法人 学会誌刊行センターの論文

著者

• KAMACHI S.

  Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• ONO M.

  Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• OH-EDA M.

  Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• KATO M.

  Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• ENDO Y.

  Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• OCHI N.

  Central Research Laboratories, Chugai Pharmaceutical Co., Ltd.

関連論文

• Structure of G-CSF: Significance of the Sugar Chain

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