The Family of Protein Kinase C in Transmembrane Signalling for Cellular Regulation

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概要

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• Signal-induced hydrolysis of inositol phospholipid produces two second messengers, diacylglycerol and inositol trisphosphate. Diacylglycerol activates protein kinase C, whereas inositol trisphosphate mobilizes Ca<SUP>2+</SUP> from its internal store. Analogously, signal-induced hydrolysis of choline phospholipid generates two second messengers, unsaturated free fatty acid and lysophosphatidylcholine. The free fatty acid synergizes with diacylglycerol to activate protein kinase C and causes full activation of the enzyme even at the basal level of Ca2+. On the other hand, lysophosphatidylcholine dramatically enhances cellular responses such as cell proliferation and differentiation under the conditions where diacylglycerol and Ca<SUP>2+</SUP> are available. It is likely that all of the immediate products of signal-induced degradation of inositol and choline phospholipids are involved directly in concert in the transmembrane control of cellular functions.

• 財団法人 学会誌刊行センターの論文

著者

• Asaoka Y.

  Biosignal Research Center Kobe University

• Ogita K.

  Department Of Pediatric Surgery Reproductive And Developmental Medicine Graduate School Of Medical S

• KIKKAWA U.

  Department of Biochemistry, Kobe University School of Medicine

• KOIDE H.

  Biosignal Research Center, Kobe University

• YOSHIDA K.

  Biosignal Research Center, Kobe University

• OKA M.

  Biosignal Research Center, Kobe University

• SHINOMURA T.

  Biosignal Research Center, Kobe University

• NISHIZUKA Y.

  Biosignal Research Center, Kobe University

関連論文

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• The Family of Protein Kinase C in Transmembrane Signalling for Cellular Regulation

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