Low Copper and Brain Abnormalities in Fetus from Triethylene Tetramine Dihydrochloride-Treated Pregnant Mouse.

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概要

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• The effects of prenatal triethylene tetramine dihydrochlo-ride (Trien-2HCl) exposure on fetal mice have been investigated on gestational day 19. Trien-2HCl was given throughout pregnancy at levels of 0 (control), 3, 000, 6, 000, or 12, 000ppm as drinking water, ad libitum. At the level of 12, 000ppm, the frequency of total resorption tended to be high and that of fetal viability tended to be low, as compared to controls. Decreased maternal weight was observed in body, but not in liver, at the level of 12, 000ppm. Fetal body and cerebrum weights significantly decreased at the levels of 6, 000 and 12, 000 ppm; however, fetal liver weight remained unchanged. Maternal serum copper concentration was not affected by the Trien-2HCl. Fetal copper concentrations of liver and cerebrum were significantly lower in the Trien-2HCl-treated groups than in the controls, with levels decreasing in a dose-related manner. When the copper and zinc concentrations in the group treated at 12, 000ppm were compared with those in controls, significant decreases in both metals were observed in placenta but not in maternal liver. Changes in fetal zinc concentration varied by tissues: i, e., an increase in liver and no change in cerebrum. Fetal abnormalities were frequently observed in brain, and the frequency was increased with increasing levels of the Trien-2HCl. These results suggest that fetal brain abnormalities caused by Trien-2HC1 may be due in part to induction of copper deficiency, which is almost equivalent to that in brindled mutant mouse.

• 財団法人 学会誌刊行センターの論文

著者

• Hayashi Yasuhisa

  Department Of Chemistry Faculty Of Science Hiroshima University

• Tanaka Harumi

  Division Of Mental Retardation And Birth Defect Research National Center For Nervous Mental And Musc

• IMAI Shoji

  Department of Biomedical Information, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• YAMANOUCHI Masahiro

  Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience

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• Low Copper and Brain Abnormalities in Fetus from Triethylene Tetramine Dihydrochloride-Treated Pregnant Mouse.

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