Photooxidation of hypotaurine to taurine in the presence of flavins.

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概要

• 論文の詳細を見る

• Irradiation of organic sulfinates such as hypotaurine and cysteine sulfinic acid in the presence of catalytic amounts of flavins led to the oxidation of its sulfinic groups (-SO2H) to the corresponding sulfonates. The process of hypotaurine oxidation in the presence of riboflavin, followed by absorbance decrease at 220 nm and by ion-exchange chromatography, showed a pseudo-first-order kinetics at pH 6.0. The k value depended linearly on flavin concentrations. The reaction rate was higher at acidic pH. Although the reaction rate was not affected by the addition of superoxide dismutase or catalase, superoxide ions were supposed to be by-products of the reaction. The effectiveness of allyl alcohol as a scavenger pointed to a free-radical mechanism of the reaction. We propose a new reaction mechanism involving sulfinic radicals on this photochemical reaction.

• 財団法人 学会誌刊行センターの論文

著者

• Dupre Silvestro

  Dipartimento Di Scienze Biochimiche Universita Di Roma 'la Sapienza'

• 細川 優

  Division of Maternal and Child Nutrition, The National Institute of Nutrition

• RICCI Giorgio

  Division of Maternal and Child Nutrition, The National Institute of Nutrition

• CHIARALUCE Roberta

  Dipartimento di Scienze e Tecnologie Biomediche e di Biometria, University of L'Aquila

• PITARI Giuseppina

  Dipartimento di Scienze e Tecnologie Biomediche e di Biometria, University of L'Aquila

• 藤井 振

  Division of Maternal and Child Nutrition, The National Institute of Nutrition

• 山口 賢次

  Division of Maternal and Child Nutrition, The National Institute of Nutrition

• PITARI Giuseppina

  Dipartimento di Scienze e Tecnologie Biomediche e di Biometria, University of L'Aquila

• CHIARALUCE Roberta

  Dipartimento di Scienze e Tecnologie Biomediche e di Biometria, University of L'Aquila

関連論文

• Simultaneous determination of urinary cystathionine, lanthionine, S-(2-aminoethyl)-L-cysteine and their cyclic compounds using liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization
• Photooxidation of hypotaurine to taurine in the presence of flavins.

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