Effect of vitamin B12-deficiency on the activity of hepatic cystathionine .BETA.-synthase in rats.

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概要

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• The effect of vitamin B12(B12)-deficiency on the activities of hepatic methionine synthase, homocysteine methyltransferase, and cystathionine β-synthase was investigated in rats. The rats bred from B12-deficient dams were fed the B12-deficient diets for 150 days after weaning. Growth retardation of the B12-deficient rats was already observed on day 30 and continued through 150 days. But dietary supplementation of 0.5% DL-methionine slightly improved the growth retardation. Urinary excretion of methylmalonic acid increased to about 15 mg/mg creatinine and hepatic B12 concentration declined to about 2 ng/g liver after a 150-day feeding of the B12-deficient diets. Hepatic methionine synthase activity in rats fed the B12-deficient diets supplemented with or without methionine decreased to about 5% of B12-supplemented controls. Hepatic betaine-homocysteine methyltransferase activity showed no significant change caused by B12-deficiency. Hepatic cystathionine β-synthase activity in rats fed the B12-deficient diets supplemented with or without methionine decreased to about 61% and 27% of their B12-supplemented controls, respectively, but the decrease was partially improved by methionine supplementation. In conclusion, the rats bred from B12-deficient dams showed a severe B12-deficiency after a 150-day feeding of the B12-deficient diets. The decrease of hepatic cystathionine β-synthase activity was supposed to be due to the adaptation by the defect of methionine resynthesis.

• 財団法人 学会誌刊行センターの論文

著者

• 飯島 健志

  Department of Food Sciences, Ibaraki Christian University

• 土居 忠

  Department of Agricultural Chemistry, Tokyo University of Agriculture

• 河田 哲典

  Faculty of Education, Okayama University

• 只野 尚登

  Department of Agricultural Chemistry, Tokyo University of Agriculture

• 前川 昭男

  Department of Agricultural Chemistry, Tokyo University of Agriculture

• 飯島 健志

  Department of Agricultural Chemistry, Tokyo University of Agriculture

関連論文

• ネパール産マスタード油の基礎的研究
• Effect of vitamin B12-deficiency on the activity of hepatic cystathionine .BETA.-synthase in rats.
• Effect of vitamin B12 deficiency on S-adenosylmethionine metabolism in rats.

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