Deterioration of membrane morphology, phospholipids, and cytoskeletal protein in rat erythrocytes exposed to tert-butyl hydroperoxide. Protection by exogenous glutathione fails in selenium deficiency.

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概要

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• Here we report scanning electron microscopy, phospholipid and fatty acid composition and cytoskeleton proteins of erythrocytes from Se-adequate and Se-deficient rats, showing protection by glutathione (GSH) against tent-butyl hydroperoxide (t-Bu00H)-induced hemolysis of erythrocytes from Se-adequate, but not from Se-deficient rats. Without exogenous GSH, erythrocytes incubated with t-BuOOH exhibited remark-able deterioration of cell membranes with diminished membrane phosphatidyl-ethanolamine, -serine, and -inositol and selective loss of a cytoskeletal protein, ankyrin 2-1. Without exogenous GSH these changes occurred in erythrocytes from both Se-deficient and Se-adequate rats. Dietary Se, through provision of glutathione peroxidase (GSH-Px) in erythrocytes as a probable scavenger of t-Bu00H, protects against hemolysis when GSH is available.

• 財団法人 学会誌刊行センターの論文

著者

• 安本 教傳

  The Research Institute for Food Science, Kyoto University

• 鈴木 鐵也

  The Research Institute for Food Science, Kyoto University

• 金 天浩

  The Research Institute for Food Science, Kyoto University

関連論文

• Tert-butyl hydroperoxide-induced hemolysis of .ALPHA.-tocopherol-decreased erythrocytes from selenium-deficient and selenium-adequate rats.
• Deterioration of membrane morphology, phospholipids, and cytoskeletal protein in rat erythrocytes exposed to tert-butyl hydroperoxide. Protection by exogenous glutathione fails in selenium deficiency.

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