Effects of .ALPHA.-tocopherol-nicotinate administration on the microdynamics of phospholipids of erythrocyte membranes in human subjects.

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概要

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• The effects of α-tocopherol-nicotinate on the microdynamic parameters, membrane viscosity, and wobbling angle of phospholipid molecules of healthy human erythrocyte membranes were studied with a nanosecond time-resolved fluorometer. The incorporation of α-tocopherol was achieved by oral administration of α-tocopherol-nicotinate for one month with dosage of 400mg/day. The increase in a-tocopherol con-centration in erythrocytes was confirmed in two subjects. The membrane viscosity in seven healthy subjects decreased significantly from 1.015±0.137 to 0.888±0.133 mPas. But no changes in the wobbling angle of phospholipid molecules were observed.

• 財団法人 学会誌刊行センターの論文

著者

• 小山 富康

  Section of Physiology, Research Institute of Applied Electricity, Hokkaido University

関連論文

• Effects of .ALPHA.-tocopherol-nicotinate administration on the microdynamics of phospholipids of erythrocyte membranes in human subjects.

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