The effect of cryosurgery on submandibular gland in the rats : Especially its functional changes.:Especially its functional changes

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概要

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• Inoue and Hayagumo froze the submandibular gland in the rat and reported the resulting changes from a histological viewpoint, proving that it was affected.<BR>The author has attempted the study to investigate how the function of the salivary gland is affected by cryosurgery.<BR>Materials and Methods: Male wistar rats weighting around 240g were used as experimental animals.The anterior part of the right submandibular gland was frozen with a probe of 4mm diameter by pressure welding, using a cryosurgery apparatus.When the surface temperature under the probe fell to -20°C or below, 30-second freezing was carried out.At 3 days, 1, 3, 5, and 10 weeks after freezing, 1% pilocarpin 8mg/kg was administered intra-abdominally to induce salivary secretion.Saliva was collected every 5 minutes and secretion volume determined.In addition, the auther observed the kinetics of protein secretory glanules in the glanular tubules cell of the submandibular gland.<BR>Results:1) When first examined, 3 days after freezing, salivary secretion volume in the frozen side showed a marked reduction, being limited to 68% of that found in the nonfreezing control group.At 1 week, the secretion volume was extremely small in both the frozen and control sides, only 23% of that found in the control group.At 3 weeks, the volume in the frozen and control sides had increased to 36% and 61% respectively of that in the control group.At 5 weeks, the frozen side showed 67% of the salivary volume in the control group, while the control side showed 97%, almost recovering to the level of the control group.At 10 weeks, the frozen side showed 75% of the volume in non-freezing group.It was demonstrated that remarkable recovery is seen in the frozen side until 5 weeks after freezing.Thereafter, recovery became more gradual.<BR>2) The submandibular gland, once frozen, showed no evidence of capacity for secretion and reaccumulation in the secretory granules even after 5 weeks following freezing.These findings have demonstrated that when the major salivary gland is frozen, a complete recovery is not expected.Therefor, in the case of cryosurgery applied not only to the salivary gland but to the adjoining region, these effects should be carefully considered.

• 社団法人 日本口腔外科学会の論文

著者

• 寺村 幸雄

  大阪歯科大学

• 寺村 幸雄

  大阪歯科大学口腔外科学教室第2講座

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• The effect of cryosurgery on submandibular gland in the rats : Especially its functional changes.:Especially its functional changes

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