口底扁平上皮癌の治療成績の検討

概要

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In order to evaluate the result of treatment and to ascertain the appropriate treatment form, fifty cases of squamous cell carcinoma of the floor of the mouth treated at the Department of Oral Surgery of Hokkaido University from 1970 to 1985 were reviewed. Eighteen patients were treated by surgery alone, 11 by preoperative radiation therapy, 6 by preoperative chemotherapy and 15 by radiation therapy alone.<BR>The 5 year survival rate was 80% in the surgical group and 50% in the non-surgical group. Recurrence of the primary tumor was found in 5.7% of the former and 41.7% in the latter. Overall regional lymph node metastasis was found on 25 patients (50%). Contralateral metastasis was found on 8 cases and it was closely related to the size and site of the primary tumor. Delayed lymph node metastasis was found on 2 of the 26 irradiated necks and on 6 of the 24 non-irradiated necks. Histopathological study revealed that cortical bone was eroded or destroyed by tumor tissues in more than half of the cases in which the primary tumor had been diagnosed as having gingival invasion or mandibular adhesion. On the other hand, clinical study showed that local recurrence was found on only one case of 16 in which the primary tumor was resected by marginal resection of the mandible.
社団法人日本口腔外科学会の論文