Somatosensory evoked potentials elicited by electric painful dental stimulation.
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概要
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The present experiment observed the SEI, dianges between different stimulus rates (1, 0.5, 0.2 Hz), subjective painfulness evaluated by Analogue Pain Scale and stimulus intensities, and the effects of low doses diazepam injection (0.01, 0.02, 0.05 mg/kg, iv), elicited by electric dental painful stimulation.<BR>Peak-to-peak emplitudes increased as stimulus rate was decreased, expecially N 160-P 260 (P<0.01), and latency of N 350 increased.<BR>No significantly changes in peak latencies were observed across different stimulus intensities. Peak-to-peak amplitude increased systematically with increased stimuli, expecially N65-P100 and N160-P260 (P<0.001). Correlation analysis was explored by linear, power and exponential regression. N 65-P 100 correlated strongly with both subjective pain scores and stimulus intensities. N160-P260 significantly correlated with subjective pain scores.<BR>Four subjects among ten of the experimental group felt sleepy from the hypnotic effect of diazepam after the total amount (0.08 mg/kg) was injected. Waveform components after 260 msec were undetectable. The experimental group's peak latencies were slowed, expecially p260 (P<0.05). N 65-P 100 amplitude was slightly increased, but P100-N160, N160-P260, P260-N350 were decreased.<BR>These findings demonstrate that amplitude measures of SEPs elicited by electric dental painful stimulation may be developed as a useful instrument for objective pain studies. Central mechanisms of diazepam were reported as midbrain excitement that inhibited sensory conduction, and infibition of hippocampal formation that released the hypothalamus function. We suggest that the enlargement of early component like N65-P100, and inhibition of later components are caused by complicated inter-neuron reaction in the central nervous system.
- 社団法人 日本口腔外科学会の論文