Experimental study as to the change of micro-structure in human malignant melanoma from gingiva cell by various antitumor agents and the antitumor effect.
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H. M. G. cell strained from the tumor cell in the pleural fluid of a patient with malignant melanoma was transplanted in a nude mouse and the tumor formed was given various drugs to examine their respective effects macroscopically, light-and electron microscopically.<BR>Drugs used are MPL, DTIC, TA-077 and CDDP as alkylating agent, FT-207 as metabolic antagonist and PSK as immunological preparation. These drugs were administered singly or combinedly (MPL+TA-077, CDDP+MPL, DTIC+FT-207 and PSK+MPL). MPL, TA-077 and CDDP showed tumoristatic effect and MPL-F TA-077 and CDDP+MPL, tumor retracting effect. PSK+MPL showed greater effect compared with single administration. However, none of the other drugs had any tumoristatic effect, with no great difference from the control.<BR>In terms of the fine structure, some changes were observed in the nucleus and intracellular organelle; specific change in mitochondria and characteristic appearance of intranuclear corpuscle were seen with CDDP and with MPL+TA-077 and CDDP+MPL, respectively.<BR>Tumor cell became larger and smaller with CDDP, MPL+TA-077 and CDDP+MPL and with TA-077, PSK and PSK+ MPL, respectively.<BR>These changes proved to be related obviously to the antitumor effect.
- 社団法人 日本口腔外科学会の論文
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- Experimental study as to the change of micro-structure in human malignant melanoma from gingiva cell by various antitumor agents and the antitumor effect.