Experimental study on regional lymph node metastasis of oral carcinomas.

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概要

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• Lymphatic metastasis is an important mechanism in the spread of human cancer Reports of experimental approach to lymphatic metastasis of oral cancer, however, are very scarce. In an attempt to establish an experimental model of lymphatic metastasis, the effects of incision and irradiation on regional lymph node metastasis in DMBA-induced squamous cell carcinoma of hamster tongue were studied.<BR>Squamous cell carcinomas of the tongue were induced by the method described by Fujita and coworkers in 127 hamsters. They were randomly divided into three groups. Group A (42 animals) remained untreated, group B (44 animals) received two parallel incisions in the center of the tumor once a week, group C (41 animals) received 3 Gy of <SUP>60</SUP>Co once after the development of tumor. The animals were killed when in obvious discomfort or following progressive weightloss to below 70 gm. The tongue, submandibular lymph nodes, lungs and liver were removed, and histologically examined.<BR>There were no appreciable changes in the macroscopic appearance and histologic features of the induced tumors among the three groups. Metastasis to the submandibular lymph nodes was confirmed histologically in 61 (48.0%) of the 127 animals. Of a total of 365 lymph nodes, metastasis was seen histologically in 102 (27.9%). The incidence of lymph node metastasis was significantly increased (65.9%) after repeated incisions of tongue carcinomas. Three Gy whole body irradiation also increase the rate of metastasis from 31.0% to 46.3%. The process of establishing metastatic foci resemble closely that seen in human carcinomas. Metastasis to the lung or liver was found in no animal. Because of the small sample size of the tumors classified in Grade Ill, nothing definite could be said about the relationship between the rate of metastasis and the malignancy grade, but endophytic type tumors with deep and diffuse invasion showed the highest incidence of metastasis.<BR>In conclusion, the DMBA-induced tongue carcinoma with incisions can be used as an experimental model of lymphatic metastasis of human oral carcinomas.

• 社団法人 日本口腔外科学会の論文

著者

• 大竹 克也

  新潟大学歯学部口腔外科学第1教室

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