口腔外科領域におけるオフロキサシン (OFLX) の組織内移行濃度に関する検討

概要

論文の詳細を見る
Ofloxacin (OFLX) a new pyridonecarboxylic acid derivative for oral use was investigated with regard to tissue transfer in the oral cavity.<BR>Ofloxacin was administered to 10 patients at a single dose of 200mg and the serum and tissue concentrations 2 hours after administration were determined.<BR>Ofloxacin was observed at a level of 2.81±1.83μg/ml in the serum, while tissue levels were determined to be 5.60±3.20μg/g in the gum, 4.75±3.43μg/g in the bone and in other tissue 1.28±5.45μg/g indicating a greater degree of transfer in the tissue as opposed to serum.