Study of the effects of endogenous tumor necrosis factor(TNF) on experimental lingual carcinoma induced by local applications of DMBA in hamsters.

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In this study, we examined the antitumor effect of a biological response modifier in relation to the induction of tumor necrosis factor (TNF).<BR>Lingual carcinoma was induced in hamsters by a local application of DMBA. The animals were divided into treated and non-treated groups where in the former received an intravenous injection of LPS or OK-432 and the latter was left as controls. All animals were further classified according to the growth pattern of lingual carcinoma, either external or internal growth. The preventive rate of tumor growth for external carcinoma was examined and the survival rate of the animals with internal carcinoma was examined.<BR>After LPS was injected into hamsters, and when a high titer of TNF was induced in the peripheral blood, lingual carcinoma was remarkably reduced. After OK-432 was injected, and when a very low titer of TNF was induced, lingual carcinoma was hardly reduced and practically remained unchanged.<BR>The survival rate of both treated animals was significantly longer than that of the nontreated ones.<BR>These results indicate that TNF plays an important role in reducing the tumor volume of external lingual carcinoma in hamsters. Furthermore, it was assumed that the reduction of tumor volume and prolongation of survival rate were of different action mechanisms.
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