舌下面に生じたリンパ上皮性嚢胞の3例とその免疫組織学的検索

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We reported three cases of lymphoepithelial cyst which arise on the base of the tongue.These cases were three females of 44, 50, and 54 year olds.Histological examination of all three cases exhibited representative lymphoepithelial cyst.The cyst was lined with squamous epithelium, and lymphoid tissues with particular germinal center appeared beneath the lining epithelium.<BR>Immunohistochemical analysis for the lymphoid tissues revealed that T cells existed in the cystic wall and mantle zone of the lymphoid follicle, while B cells mainly accumulated in the germinal center.A large number of immunoglobulin containing cells were found between the lining epithelium and follicles, which IgG containing cells were seen most frequently. Anti-lysozyme positive cells were found just under the epithelium.These results suggest that an antibody production of lymphocytes occured directly against localized antigens from lumen or secondary infection.