Experimental study on the carcinostatic effects of peplomycin on tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO) in rats.
スポンサーリンク
概要
- 論文の詳細を見る
We examined the antitumor effect of peplomycin morphologically using a rat model of tongue carcinoma induced by the carcinogenic agent, 4-nitroquinoline 1-oxide. We also studied the survival status of reproliferative tumor cells and the reproliferative movement of the tumor after the completion of peplomycin treatment.<BR>The effective rate of peplomycin was 25.5% if tumors showing a reduction of 1/2 or greater are designated as a positive response or 5.9% if histological evidence of Grade III or above is regarded as a positive response.<BR>We noted a correlation between clinical macroscopic type and the mode of invasion. The frequency of ingrowing growth patterns such as ulcer type was statistically hingher in types 4 C and 4 D, while outgrowing growth patterns were more commonly noted in types 1 to 3.<BR>We also noted that the higher the tumor invasion, the lesser was the antitumor effect both macroscopically and histologically. Therefore, when carrying out neo-adjuvant chemotherapy with peplomycin, the mode of tumor invasion can be an important factor in forecasting the effect of treatment.<BR>Even after the macroscopic eradication of the lesion by peplomycin treatment, we sporadically noted some sections with histological evidence of surviving tumor cells. Although the antitumor effect of peplomycin remained up to 20 days after completing treatment, it was most remarkable 10 days after treatment histologically.<BR>Macroscopically, tumors of ulcer type showing A type 4 C or 4 D mode of invasion were characterized by rapid reproliferation of surviving tumor cells and strongly tended to be heteromorphic.<BR>It was concluded that peplomycin preoperative chemotherapy is most effective when treatment is planned so that surgery can be carried out within 10 days after completing chemotherapy.
- 社団法人 日本口腔外科学会の論文
著者
関連論文
- 当講座で行っている口腔癌検診の現状と将来展望 : 歯科医師会と協力して行っている口腔癌検診
- 移植皮膚片の固定のためのシアノアクリレートの応用
- 口腔領域にみられた sinusoidal Hemangioma の5例
- 舌癌 excisional biopsy におけるヨード生体染色の有用性
- 口腔扁平上皮癌周囲にひろがるヨード不染部のテロメラーゼ活性定量と組織学的所見
- 悪性腫瘍follow-up外来開設 : 1年間の結果報告
- エナメル上皮腫の治療法に関する臨床統計的検討
- 千葉市で行われている口腔癌検診について : 実施方法の検討
- 下顎骨切除手術時に下歯槽神経引き抜き再縫合法を行った5例 -特に術後知覚回復過程の観察について-
- 下歯槽神経修復手術の臨床的検討 : 特に神経移植症例について
- 側頸部原発と考えられた扁平上皮癌の1例 : Martin の診断基準を満たしていると考えられた鰓原性癌について
- 成人の顎下部に発生した嚢胞性リンパ管腫の1例
- A method of reconstruction of parotid duct using buccal mucosa.
- Experimental study on the carcinostatic effects of peplomycin on tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO) in rats.