Ability of bone induction and activity of TGF-.BETA. in demineralized bone obtained from different aged rats. Change by aging.:Change by aging

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Bone morphogenetic protein (BMP) and transforming growth factor-β(TGF-β) are present in bone tissue. These proteins are known to be associated with bore formations.However, the biological functions of these proteins are not yet fully clarified. In this study, the author examined bone induction and TGF-β activities using the pellets of the demineralized bone matrix and 4M guanidine hydrochloride extracts of bone matrix which were obtained from different aged rat tibia. Furthermore, the relationships between these activities and calcium content or morphology of materials are studied.<BR>The results showed that bone induction did not take place in the demineralized bone pellets of the fetus and neonatus, whereas it was found in those of 8-and 12-week-old rats. TGF-β activity was detected in all materials and its activity increased with bone maturation. Investigating the calcium contents and morphology of materials used in this experiment, the tibias obtained from 8-and 12-week-old rats consisted of mature lamellar bore and contained considerable amount of calcium, revealing well mineralization of these tissues.<BR>These results indicate that the activities of bone induction and TGF-β of the tibia was related to bone maturation.
社団法人日本口腔外科学会の論文