Bone resorption activity of ameloblastoma.
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概要
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The bone resorption is involved in the growth of ameloblastomas, however, the mechanism of bone resorption by this tumor remains unclear whether tumor cells directly resorb bone, tumor secretion enhances the activity of osteoclasts, or tumor secretion or tumor itself stimulates peripheral blood leukocytes (PBL) to release osteolytic factors.<BR>In this study, four ameloblastomas, which were successful in primary cultures out of the cases histologically diagnosed ameloblastoma during the period of 1990 to 1991 at Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, were investigated. The mechanism of bone resorption was examined using the three <I>in vitro</I> assays with mice: a new born calvaria culture system, a bone marrow culture system and a peritoneal macrophage chemotaxis. The tumor homogenates, the tumor conditioned media, the monocyte conditioned media stimulated by tumor homogenates or conditioned media, and the lymphocyte conditioned media stimulated by tumor homogenates or conditioned media were obtained for samples. The results were:<BR>1. Ameloblastoma during their growth released soluble factors which had bone resorption activity and regulated the multinucleated cell formation.<BR>2. The tumor secretion stimulated PBL and induced the release of osteolytic factors.<BR>3. The activity of osteolytic factors was inhibited by indomethacin. Thus, it was suspected the involvement of prostaglandins in this process.<BR>4. Tumor itself did not affect either the bone resorption activity or PBL stimulation.<BR>5. Tumor secretion had chemotactic activity on mouse peritoneal macrophage, however, the magnitude was low. This might induce the migration of osteoclasts.<BR>6. There is a possibility that ameloblastomas may express the different bone resorption activity along with the histological types.
- 社団法人 日本口腔外科学会の論文