口腔扁平上皮癌に対するTPP動注化学療法の試み

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The authors designed a regimen of TPP intra-arterial chemotherapy (THP-ADM, CDDP and PEP) for the treatment of oral squamous cell carcinomas. Twenty-one patients were treated, and markedly effective results were obtained. The regimen of TPP intra-arterial chemotherapy was 20 mg/m2 of THP-ADM on day 1 (one shot), 50 mg/m2 of CDDP continuous infusion on day 2, and 5 mg/m2 of PEP from days 3 to 7. After 2 weeks of no treatment, the above regimen was repeated every three weeks. As a rule, 2 cycles were performed. One cycle was received by 3 cases, and 2 cycles were received by 18 cases. The median age of the patients was 57. 1 years old (15 males, 6 females). Primary lesions involved the tongue in 8 cases, maxillary sinus and mandibular gingiva in 3 cases each, buccal mucosa and oral floor in 2 cases each, and the palate, oropharynx and mandibular central carcinoma in 1 case each. TNM classification was Tis in 1 case, T2 in 7 cases, T3 in 1 case, and T4 in 12 cases. All cases were MO. The clinical response was CR in 6 cases (28. 6%), PR in 14 cases (66. 7 %), and MR in 1 case. The response rate was 95. 2%. Among the 8 cases of tongue carcinoma, 4 were CR (50%) and 4 were PR for a response rate of 100%. The response to this chemotherapy of metastatic regions in 11 cases involving the submandibular and cervical lymph nodes was CR in 1 case and PR in 10 cases. The response rate of metastatic lymph nodes was therefore 100%. The main side effects were hair loss on the treated side in 20 cases (95. 2%), anorexia in 18 cases (85. 7%), stomatitis in 17 cases (80. 9%), nausea and vomiting in 11 cases (52. 4 %), facial flush in 10 cases (47. 6%), and fever in 7 cases (33. 3%). Leukopenia (57. 1%) and thrombocythemia (23. 8%) were noted as laboratory abnormalities, but there were no severe cases.
社団法人日本口腔外科学会の論文

口腔扁平上皮癌に対するTPP動注化学療法の試み

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