実験的Lalhyrismによる歯周組織の変化に及ぼすSaliva-Parotinの影響
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The administration of aminoacetonitrile to rats is very effective to produce mesenchymal lesions characteristic for lathyrism. With the exception of enamel, dental tissues are of mesodermal origin.<BR>Since aminoacetonitrile is known to exert profound effects upon connective tissues, further knowledge of its effects, if any, upon these types of mesodermal tissue would be mostly expected.<BR>It is very interesting for us to investigate these problems, because we have elucidated pathologic responses of paradental tissue by many stressors.<BR>Parotin, found by Prof. T. Ogata, is an extract of parotid glands of cow. Parotin, is said, stimulates the vitality of the all mesenchymal tissues. T. Ogata and his collaborators also found the fact that parotid glands of rabbits or rats became hypertrophic and increased their function after the extirpation of their submaxillar glands by compensaton.<BR>The author found a characteristic change of Lathyrism in the paradental tissue and jowl of rats after administration, of aminoacetonitril. A continuous administration of parotin as well as an extirpation of submaxillary glands were effective to suppress the developments of Lathyrism in the paradental tissue and jowl bone of rats.<BR>These changes were more remarkabl in the weanling rats. Prof. H. Selye reported the lathyrismic change in rats was aggravated by the injection of somatotrophic hormone.<BR>Pror. Tasaka and Shibata published a paper that a long-term administration of parotin followed atrophy of parotid glands and decrease of the secretion of hypophyseal hormones. In this connection, the author's finding would be discussed. Male rats of Wistar strain, weighing about 100g were used and the histological preparations were made by Hematoxilin-Eosin or Mallory dyeing.
- 有限責任中間法人 日本口腔衛生学会の論文